Bence Jones proteins and light chains of immunoglobulins. XI. A transient Bence Jones-related protein associated with corticosteroid therapy.
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منابع مشابه
Bence Jones proteins and light chains of immunoglobulins. XI. A transient Bence Jones-related protein associated with corticosteroid therapy.
Urine specimens from patients with multiple myeloma and Bence Jones proteinuria frequently contain low molecular weight proteins which correspond either to the amino-terminal, variant half (VL) or to the carboxyl-terminal, constant half (CL) of the Bence Jones protein. Analyses of urine specimens from such patients who had received high doses of corticosteroids as part of their treatment regime...
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The primary structure of Bence-Jones proteins is characterized by a variable amino acid sequence in the aminoterminal half and a constant amino acid sequence in the carboxyl-terminal half. Proteins corresponding either to the variant half or to the constant half of whole Bence-Jones proteins have been detected in urine of patients with multiple myeloma. Both halves of a Bence-Jones protein were...
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The light (L) polypeptide chains of the human T-globulins carry antigenic determinants designated as group 1 or 2 (1-3). Allotypic determinants designated InV have been found in association with the L chains of 3,,-globulin (4). Natural ly occurring human ant ibody directed toward L chain determinants has been described in detail only for the InV antigens (5). The present studies utilize human ...
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Plasma cell disorders are important in the differential diagnosis of acute kidney injury and of renal impairment with proteinuria. One or more of several mechanisms can be involved, such as cast nephropathy, deposition of monoclonal immunoglobulins, formation of amyloid fibrils, hypercalcaemia, hyperuricaemia and a variety of tubular syndromes. Various tests, such as serum electrophoresis and i...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1975
ISSN: 0021-9738
DOI: 10.1172/jci107965